Genome-wide genotyping for all samples from England, Finland, Iceland and Italy was carried out at deCODE Genetics using the Illumina HumanHap300 chip (San Diego, CA). For the samples from Germany/Munich and Scotland, approximately one-third of both cases and controls were genome-wide typed at deCODE using the Illumina HumanHap300 chip, whereas the remaining two-thirds of cases and controls were genome-wide typed at Duke University using the Illumina HumanHap300 (Germany) and Illumina HumanHap550 (Scotland) chips. For the samples from the Netherlands, 715 cases and 643 controls were typed at UCLA using the Illumina HumanHap550 chip, whereas 3334 additional controls were typed at deCODE using the Illumina HumanCNV370 chip. The samples from Germany/Bonn were genome-wide typed at the University of Bonn using the Illumina HumanHap550 chip. The samples from Denmark were typed at deCODE Genetics using the Illumina HumanHap610 chip. For all the chips, yield for the two markers used for the surrogate (rs12477914 and rs1366840) was at least 98% and, in the controls of each group, neither marker deviated significantly from Hardy–Weinberg equilibrium (P > 0.05). For both the markers used, when
