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Chunk #33 — Discussion — rs-fcMRI may reflect an interaction between the maturing neural substrate and the use of efficient pathways for general task completion — Changes in the neural substrate over development may lead to more efficient neural pathways for general task completion

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Functional brain networks develop from a "local to distributed" organization.
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In other words, as myelination continues through development and allows for more effective long-distance neural pathways, repeated co-activation becomes more prevalent between many distant regions, and less so between many locally aligned regions, thus changing synaptic efficiencies. The statistical histories of such interactions, stored as relative synaptic weights, are then revealed via rs-fcMRI, and would lead to the “local to distributed” organization principle seen here.