n = 8,367). Both WHI and CARe datasets were obtained from dbGaP (accession numbers: phs000386 for WHI; CARe including phs000557.v4.p1, phs000286.v5.p1, phs000613.v1.p2, phs000284.v2.p1, phs000283.v7.p3 for ARIC, JHS, CARDIA, CFS and MESA cohorts) and processed following the protocol provided by the dbGaP data submitters. After excluding samples with more than 10% missing values and retaining only unrelated individuals, our final LD reference included data from n = 10,636 unrelated AFR individuals. For HIS, we used genotypes at 1,246,763 sequenced HM3 SNPs (MAF > 1%) from n = 4,883 unrelated samples from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; dbGaP accession number: phs001395.v2.p1) cohorts. Finally, we performed a COJO analysis of the combined meta-analysis of all ancestries (referred to as METAFE in the main text) using 348,501 unrelated EUR participants in the UKB as the reference panel.
