The high genetic correlation between AD and AC-quantity (rgAD−AC quantity = + 0.75, 95%CI = (0.56, 0.94), P = 1.8 × 10−14) (Fig. 1) suggests that these phenotypes capture overlapping constructs and that quantity of consumption is an indicator of problematic alcohol use. Of note, the genetic correlation between AD and AC-frequency is not significantly different from zero, indicating that it is not a reliable indicator of genetic risk for AD.
