cell lines using shRNA sequences. IdoA was shown to facilitate the binding of HGF to its receptor and was essential for cMET-dependent signalling 13 (Fig. 4F). In addition, DS-epi1 down-regulated cells displayed fewer cytoplasmic stress fibres than control cells. Furthermore, the focal adhesion complexes were evenly distributed at the cell surface in DS-epi1 down-regulated cells compared to control cells, which displayed focal adhesion complexes predominantly at the leading edge. This resulted in less migration and invasion of DS-epi1 down-regulated cells compared to control cells 13.
