chromosome can be completed within an hour using one Intel(R) Xeon(R) CPU core and 2 GB of memory. Expanding the size of LD blocks may improve prediction accuracy but increases computational cost (as each MCMC iteration requires inverting an L × L matrix where L is the block size), while reducing the size of LD blocks has the potential risk of missing long-range LD. Therefore, the partition we chose represents a balance between modeling accuracy and computational burden. Including multi-million SNP predictors may increase prediction accuracy28 but requires further work.
