Given the suggestion that there might be an interaction between CNR1 variation and olanzapine on the rewarding effects of alcohol, we reanalyzed data from a recent clinical trial of olanzapine.34 This study examined the effects of olanzapine (5 mg) on cue-elicited craving and drinks per drinking day during a 12-week trial in a sample of treatment-seeking alcohol-dependent individuals. In the reanalysis, rs2023239 was included as a moderator. There were 23 individuals in the CT group and 46 individuals in the TT group. The analyses revealed a significant medication × genotype × cue interaction on craving (F1,65 = 5.29, P < .05) such that individuals with the CT genotype reported greater cue-elicited craving when treated with placebo vs olanzapine (Figure 5A and B). Individuals with the CT genotype reported greater drinks per drinking day compared with individuals with the TT genotype when treated with placebo vs olanzapine (F1,65 = 3.94, P = .05) (Figure 5C and D).
