Chunk #10 — Results — Generation of ciBECs with Four Cell Populations Derived from hiPSCs

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In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling.

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We induced ciBECs with two hiPSC lines, 201B6 and 836B3. Furthermore, we performed the chimera differentiation assay, in which 836B3 iPSC-derived ECs and pericytes were co-cultured with 201B6 iPSC-derived neurons and astrocytes. This method also was able to generate ciBECs (Figure S3). These results indicated that our method is robust for generating ciBECs.