To test whether these large differences in leptin turnover contribute to Cyp1b1 effects on adiposity, we bred the Cyp1b1-ko allele into ob/ob mice, which are leptin deficient. The ob/ob mice develop extreme obesity due to enhanced food consumption and reduced metabolic rate and thermogenesis [21]. The enhanced adiposity of ob/ob mice was completely unaltered by Cyp1b1–deletion (Figure 4E), in contrast to a similar intervention produced by Scd1 deletion [40]
