Haplotype analyses were performed in the EA population using the sliding window approach in PLINK (18), and results for 10-SNP windows are highlighted. We used OMNIBUS p-values for the primary analysis and individual haplotype p-values for the analysis of haplotype heterogeneity at ANK3. In these analyses, population structure was not taken into account. For the haplotype heterogeneity analysis at ANK3, the proportion of haplotypes that reached a p-value of p < 0.05 was performed using the 10-SNP window results. For each window, the number of haplotypes with an individual p-value less than 0.05 was counted and a proportion calculated for the window. Smoothing was performed over the results for the rest of the genome, and regions were highlighted that had a smoothed proportion greater than or equal to the maximum found at ANK3 (0.33). Regions were distinct and were delineated by the first and last marker with a smoothed value greater than or equal to 0.33.
