without dementia who agree to annual clinical evaluation and organ donation. However, it enrolls participants with a much wider range of life experiences and socioeconomic status with a goal of enrolling a third of participants with 12 or fewer years of education. Further, the study requires that participants agree to donate spinal cord, muscle and nerve, in addition to brain, to support studies of decline in motor function and disability as well as cognitive function. More recently, participants have been encouraged to participate in a variety of additional studies including studies of physical activity and sleep using actigraphy, structural and resting state functional magnetic resonance imaging (fMRI) studies, and studies of well-being, behavioral economics, and health and financial decision making.
