We first conducted a meta-analysis of GWA studies of BMI and ~2.8 million imputed or genotyped SNPs using data from 46 studies including up to 123,865 individuals (Online Methods, Supplementary Fig. 1 and Supplementary Note). This stage 1 analysis revealed 19 loci associated with BMI at P < 5×10−8 (Table 1, Fig. 1a and Supplementary Table 1). These 19 loci included all ten loci from previous GWA studies of BMI6–10, two loci previously associated with body weight10 (FAIM2 and SEC16B) and one locus previously associated with waist circumference14 (near TFAP2B). The remaining six loci, near GPRC5B, MAP2K5/LBXCOR1, TNNI3K, LRRN6C, FLJ35779/HMGCR, and PRKD1, have not previously been associated with BMI or other obesity-related traits.
