press, and Supplementary Table 1), but the p-value for association between “dizziness” and rs16969968 is 0.40. Nor did we find evidence for association between “pleasurable buzz” and rs16969968 (p=0.43, data not shown). This lack of association highlights the challenge of finding and understanding genetic components for complex disorders. Although “dizziness” and “pleasurable buzz” are highly predictive of nicotine dependence and likely to be an informative phenotype for understanding some genes related to smoking behavior, they do not explain the association of the CHRNA5/A3/B4 cluster with nicotine dependence in this sample.
