when using LD Hub (and LD score regression in general), since the inclusion of these SNPs could unduly leverage the regressions and consequently the estimates of genetic correlations and SNP heritability. However, with the exception of autoimmune diseases (SNPs in the MHC can have large effects on certain autoimmune diseases), it is unusual for common traits/diseases to exhibit a single locus of large effect, and thus this potential source of bias should not be an issue for a majority of diseases/traits. For traits that exhibit a single locus of disproportionately large effect (χ2 > 80), we recommend fine-mapping and direct evaluation of overlap in the particular region to assess whether genetic effects are shared, and LD score regression of the rest of the genome with this particular region excluded from analyses. After the abovementioned quality control steps, 1 215 002 SNPs were selected for upload.
