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Chunk #43 — Discusion

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Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.
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used to induce neuroectoderm from hPSCs, Bagley et al. do not include specific neural induction factors. In forming fused organoids, Bagley et al. used a single Matrigel droplet to embed two organoids (Bagley et al., 2017), while the static fusion was applied by us and Birey et al. Despite these differences, all three groups observed a robust interneuron migration in the fused organoids, which provide an excellent model to study mechanism of human interneuron migration in vitro.