Adipose tissue secretes numerous adipokines that contribute to a wide array of biological processes. CTRP3, is a novel and unique member of the adipokine superfamily which appears to have a unique roles in a variety of tissue: hepatic lipid metabolism, cardiovascular response to ischemia, and chondrocyte proliferation and differentiation. CTRP3 can function in an autocrine, paracrine, and endocrinemanner and there are many aspects of CTRP3’s regulation and function that have yet to be explored. In addition, CTRP3 has been consistently linked to activation of the PKA signaling pathway, regardless of the tissue/treatment paradigm examined (37, 47, 80). This review should serve as a basis for the design of future experimental studies specifically examining: (i) the regulation of CTRP3 in response to food intake or exercise, (ii) associations between circulating CTRP3 levels, including the two different splice variants (CTRP3A and CTRP3B), and hepatic steatosis or osteoscarcoma in clinical population, and (iii) the associations between the different CTRP3 isoforms (CTRP3A and CTRP3B) and multimeric structures in clinical populations, (iv) the potential use of CTRP3 as an inhibitor of inflammation, and (v) whether
