As seen in Fig. 1, HCs displayed a step-wise attenuation (slowing) in the rate of CT loss with increasing Val dose within widespread bilateral PFC (medial and lateral aspects), temporal, and superior parietal regions (co-ordinates for peak vertices in each region are provided in Supplementary Table 2). As a result, although increasing Val dose was significantly associated with less CT in these cortical areas at age 10 years, this relationship was lost (bilateral temporal, left lateral PFC and anterior cingulate) or inverted (bilateral middle cingulate, left superior parietal and right lateral PFC) by age 20 years.
