Brain dysfunction, especially the frontal lobe changes, associated with chronic alcoholism and a predisposition to develop alcoholism has been well documented by neurophysiological, neuroimaging, and neuropsychological studies (see Moselhy et al. [1] for a review). Over the decades, there has been compelling evidence for brain abnormalities in ‘nonamnesic’ chronic alcoholic patients as well as in their high-risk offspring from electrophysiological [2-12], neuroimaging [13-20], and a wide range of neuropsychological investigations [21-28].
