Chunk #22 — Results — Genotyping Additional PPP3CA Variants in Substance Dependent and Control Samples

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Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.

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For the other markers (Tables 1 and 2), allele or genotypic frequency differences did not reach statistical significance. Distributions of allele and genotype frequencies for the promoter SNP rs2850328 deviate from Hardy-Weinberg equilibriums, especially in the African–American substance dependent samples (Table 2; χ2 p-value = 9.95 × 10−4).