Chunk #12 — Results — eQTL at a common inversion polymorphism on chromosome 17q21 — Enrichment of fetal brain cis-eQTL within genetic variants associated with neuropsychiatric traits
8), using a method that accounts for allele frequency, linkage disequilibrium, and local gene density [38]. As a comparison, we performed identical analyses on similar sized GWAS data for five non-brain traits (body mass index, coronary artery disease, inflammatory bowel disease, height, and type 2 diabetes) [39–43]. Fetal brain transcript eQTL were notably enriched (P < 0.001) within trait-associated variants for three neuropsychiatric disorders (attention deficit hyperactivity disorder, bipolar disorder, and schizophrenia) and one non-brain trait (inflammatory bowel disease) at one or more GWAS P value threshold (Fig. 3; Additional file 1: Table S7).
