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Chunk #31 — METHODS — Samples, quality control and imputation. — iPSYCH.

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Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.
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The iPSYCH15,70 cohort consists of 129,950 genotyped individuals, among which 85,891 are cases diagnosed with at least one of six mental disorders (i.e., ADHD, SCZ, BD, MDD, ASD, post-partum disorder) and the remaining are population-based controls. Samples were selected from a baseline birth cohort comprising all singletons born in Denmark between May 1, 1981, and December 31, 2008, who were residents in Denmark on their first birthday and who have a known mother (n = 1,657,449). ADHD cases were diagnosed by psychiatrists according to the ICD10 criteria (F90.0, F90.1, F98.8 diagnosis codes) identified using the Danish Psychiatric Central Research Register71 and the Danish National Patient register72. Diagnoses were given in 2016 or earlier for individuals at least 1 year old. Controls were randomly selected from the same nationwide birth cohort and not diagnosed with ADHD.