Two web resources for investigating psychiatric genetics findings are shown in Table 1 (Allen et al., 2008, Konneker et al., 2008). GWAS analyses described above take an agnostic approach to GWAS data. Experience gleaned from other diseases indicates that SNPs identified and confirmed by replication are not necessarily those with the smallest p-values in an initial study. Bioinformatics approaches can be useful in annotating and organizing GWAS SNP data to identify SNPs for replication. SNPs may be prioritized based on many additional types of information: previous genetic association data; by location in exons, putative functional regions of the genome, or in brain-expressed genes; or on the basis that the identified SNP allele has an effect on gene expression in brain (Xu and Taylor, 2009).
