our observation that when comparing striatal gene regulation among F2, HS4 and HS-CC mice (Iancu et al. 2010) module annotation is more consistent than the alignment of genes within specific modules. For example, Ras/MAPK pathways have been repeatedly associated with the risk for excessive preference consumption (see above) but generally from the perspective of differential gene expression. In the current study, these pathways appeared prominent in the cosplicing data, suggesting a more subtle form of transcriptome regulation. However, we also note that selection from the HS-CC detected very broad effects on cell adhesion molecules and showed that long non-coding RNAs may have a prominent role in preference genetics.
