First, we compared the three AUDIT-C metrics (closest, highest, and trajectory) using the following pairwise comparisons: closest vs highest; closest vs trajectory; and highest vs trajectory. We also generated Spearman correlation coefficients between the three AUDIT-C metrics. Next, median PEth values were summarized and categorized by cutoff values (>8, >20, >100 ng/mL). The associations of the three AUDIT-C metrics with PEth were tested using non-parametric tests for trend for continuous PEth values and chi-square tests for trend for dichotomous PEth variables. Among AAs, the associations of AUDIT-C metrics with rs2066702 were tested using chi-square tests for trend.
