paperKB
coga / coga-kb
Help
Sign in

Chunk #10 — METHODS AND MATERIALS — Statistical Analysis Methods

Source
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.
Embedded
yes

Text

number of SNPs tested). Results were not adjusted for testing in two populations because we tested three distinct a priori hypotheses: SNPs are associated with FTND in AAs, SNPs are associated with FTND in EAs, and associations are evident with the same SNPs in meta-analysis in AAs and EAs. In EAs, we had 80% power to detect SNPs explaining 1% of the total variance in FTND score and the same power to detect SNPs explaining 2% of the trait variance in AAs (24).