The effects of variants on lung function in children were also tested in 5,062 children from ALSPAC (mean age 8.6) and 1,220 children from the Raine study (mean age 8.1). Data were available for 81 of the 97 variants (a proxy variant with r2>0.7 was used for 11 signals) with imputation quality >0.5 of which 73 had imputation quality >0.8 (71 variants in ALSPAC and 35 in the Raine study). Association results from the two cohorts were combined using inverse variance weighted meta-analysis. A weighted risk score was approximated using pooled single SNP results, as described in Dastani et al52, and weights obtained using estimated effect sizes from either SpiroMeta15 summary data (for SNPs discovered in UK Biobank), or from UK Biobank (for SNPs discovered elsewhere). The risk score was tested for the three lung function traits: FEV1, FVC and FEV1/FVC.
