(Wang X. et al., 2016). Meanwhile, mice primary hepatocytes treated with 18-carbon FA also express more Nrf2 and CYP2A5 than the control cells (Cui et al., 2016). Thus, we hypothesize that HFD-induced hepatic 18-carbon FA accumulation up-regulates CYP2A5 in hepatocytes steatosis may correlate with the activation of Nrf2. Whether Nrf2 expression is necessary for CYP2A5/2A6 up-regulation in hepatocellular steatosis has never been reported. Our study aims to investigate the necessity of Nrf2 expression for hepatic 18-carbon FA accumulation induced CYP2A5/2A6 up-regulation.
