The resources described here include documentation, other explanatory material and references to collaborators and data sources on the respective web sites. The NCBI Help Manual and the NCBI Handbook, both available in the NCBI Bookshelf, describe the principal NCBI resources in detail. Several tutorials are also offered under the Education link from the NCBI home page. A Site Map provides a table of NCBI resources, and the About NCBI pages provide bioinformatics primers and other supplementary information. A user-support staff is available to answer questions at info@ncbi.nlm.nih.gov. Updates on NCBI resources and database enhancements are described in the NCBI News newsletter (www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=newsncbi). In addition, NCBI supports several mailing lists that provide updates (www.ncbi.nlm.nih.gov/Sitemap/Summary/email_lists.html), as well as RSS feeds (www.ncbi.nlm.nih.gov/feed/).