3) These genes do not overlap, to extents greater than expected by chance, with genes listed in the Knowledgebase for Addiction Related Genes (KARG), a recent compilation of literature and database information concerning addiction related genes [49]. 4) Gene ontology searches (BioBase) reveal “Biological Process” terms that displayed the strongest trends toward overrepresentation (compared to Bonferroni-corrected p = 7.8×10−5) among human gene classes: glutamate signaling pathway (p = 0.00019); auditory receptor cell differentiation (p = 0.0047); endocytosis (p = 0.0065); sex determination (p = 0.0081); inner ear receptor cell differentiation (p = 0.0081); endothelial cell proliferation (p = 0.0088); synaptic transmission (p = 0.01); mechanoreceptor differentiation (p = 0.01); adult locomotor behavior (p = 0.01) and regulation of synaptic plasticity (p = 0.01). Mouse data for glutamate signaling pathway (p = 8.2×10−6) provides the strongest p values that do exceed the Bonferroni correction (data not shown).
