In summary, we found an association between DRD2 and two impulsivity phenotypes. This experiment was highly controlled and involved a sample of healthy volunteers. The findings add to our understanding of genetic effects on neurobiological mechanisms of inhibition and impulsivity. Our finding that the DRD2 genotype—in particular, the recently discovered promoter SNP rs12364283—influences both behavioral inhibition and self-reported measure of impulsivity demonstrates a common genetic influence on experimentally and interview-based measures of impulsivity.
