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Chunk #47 — Materials and Methods — Selection of variants for replication

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Discovery of novel heart rate-associated loci using the Exome Chip.
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in LD (r2 < 0.2) with the published SNV in that region. LocusZoom plots were produced for all selected SNVs. Only the lead SNV was carried forward, for each signal being followed up. Specifically, the most significantly associated SNV was selected for any SNVs in pairwise-LD (r2 > 0.2). LD was calculated within UK Biobank genetic data, in order to calculate pairwise-LD for all 21 known SNVs (not only those covered on the Exome Chip).