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Chunk #15 — Glutamate and GABA Signaling in D1 vs. D2 MSNs

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The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons.
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et al., 2010), particularly the dendritic alterations observed after cocaine exposure selectively in the D1+ MSNs (Lee et al., 2006; Kim et al., 2011) which may be associated with the increase in miniature excitatory postsynaptic currents observed in D1+ MSNs (Kim et al., 2011). Interestingly, ΔFosB induction in D1+ MSNs has been related directly to such dendritic adaptations after chronic cocaine (Maze et al., 2010).