Obesity and chronic over-nutrition are the major risk factors for the development of NAFLD [4]. NAFLD is also considered the hepatic manifestation of the metabolic syndrome [5]. Although several mechanisms of NAFLD/NASH development have been proposed, its pathophysiology is still elusive. The incidence of insulin resistance (IR) or type-2 diabetes mellitus with NAFLD suggests that there is a positive association between IR and the pathogenesis of NASH [6]. However, the role of IR in the development and progression of NAFLD is unclear.
