eCB signaling robustly modulates GABAergic signaling in the BLA (see figure 1b). DSI and LTDi are expressed by BLA pyramidal neurons. While DSI is mediated via 2-AG, the identity of the eCB ligand subserving LTDi remains controversial. Circuit levels analyses reveal that LTDi in the BA facilitates activation of BA-CeA pathway. At glutamatergic synapses onto BLA neurons, 2-AG mediates DSE, and eCB ligand mediating amphetamine-LTD is not known. In general, the BA exhibits more robust eCB signaling than the LA. eCB signaling also modulates excitatory transmission between the BA and efferent targets, including the nucleus accumbens and prefrontal cortex. Within the CeAM, eCB-mediated DSI and DSE have also been demonstrated
