previously been implicated in BD12,18,59. Although BD-associated SNPs in this locus are known to regulate TRANK1 expression76, our eQTL analyses support a stronger but correlated regulation of DCLK3, located 87 kb upstream of TRANK143,77. Both FURIN and DCLK3 also encode druggable proteins (although they are not targets for any current psychiatric medications)73,78. These eQTL results provide promising BD candidate genes for functional follow-up experiments29. While several of these are in genome-wide significant loci, many are not the closest gene to the index SNP, highlighting the value of probing underlying molecular mechanisms to prioritize the most likely causal genes in the loci.
