As in prior studies, women reported greater depression symptoms (Kessler, 2003) while men reported more problematic alcohol use (Hasin et al. 2007) and had higher bilateral reward-related VS reactivity to positive feedback (Spreckelmeyer et al. 2009; Nikolova et al. 2012); Supplementary Table S2). Age was associated with self-reported substance-mediated coping as well as problematic drinking, where those in the legal North Carolina age group (i.e. over 21) reported more substance-related coping and problematic usage. Ethnicity predicted self-report measures of depression, stress, and alcohol use (Supplementary Table S3).