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Chunk #28 — Discussion

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Comprehensive analyses of RNA-seq and genome-wide data point to enrichment of neuronal cell type subsets in neuropsychiatric disorders.
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We envision three broad implications for psychiatry as a medical specialty. First, our results consistently point to specific neuronal cell types being implicated in several psychiatric disorders. Therapeutic targeting of those cells could one day result in innovative treatments. Second, gene sets that are specifically enriched in those cells (for instance hippocampal pyramidal cells) could be used for risk scoring to stratify patients and tailor therapy. Third, for the disorders with less consistent results, clinicians and researchers should aim to collect more samples and thus ensure future studies may shed light on their implicated cell types.