mPFC is a target for glucocorticoids as evidenced by the growing literature that shows the damaging effects of stress and corticosteroid treatment on the structure of the mPFC (Cook & Wellman, 2003; Brown, Henning & Wellman, 2005; Cerqueira et al., 2007). Interestingly, the damaging effect of stress on the mPFC has been shown to be reversible in both humans (Liston et al., 2009) and rats (Radley et al., 2006). This growing body of literature indicates that the mPFC is a very plastic and thus very susceptible brain region which is markedly sensitive to the effects of teratogens and environmental factors.
