brain tissue have been found hyper-methylated in human alcoholics (Bönsch et al., 2006; Muschler et al., 2010; Heberlein et al., 2011; Taqi et al., 2011). In this section, we focus on recent studies demonstrating that miRNAs can regulate epigenetic factors and vice versa (Sato et al., 2011), highlighting, in particular, epigenetic-related miRNAs upregulated in the brain of human alcoholics. We summarize this evidence in the hypothetical models presented in Figures 1 and 2 (see nucleus).
