Chunk #54 — Materials and Methods — Algorithmic details for gene-score calculations — Sum-score

Source: Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics.
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The algorithm relies on the Davies algorithm to calculate distribution function values of weighted sums of independent χ12-distributed random variables[47]. In case of convergence problems the Farebrother algorithm is used as a backup[48,49].