Beneficial effects of gabapentin for the treatment of alcohol dependence were found in the intention-to-treat population over the 12-week course of treatment on: 1) the rates of complete abstinence and no heavy drinking, 2) the number of heavy drinking days and the number of drinks consumed per week, and 3) severity of craving, insomnia, and dysphoria. Results followed a linear dose-effect, with greatest efficacy achieved at the 1800 mg dose. Laboratory measures of GGT provided validation of gabapentin's effects on self-reported drinking outcomes. Significant effects were found to persist post-treatment in study completers who participated in the Week 24 follow-up assessment.
