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Chunk #30 — Results — Changes in gene expression in the VTA

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Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats.
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Among the 211 unique named genes that differed (FDR = 0.1) between the ethanol and water groups in the VTA, there were 26 genes located within rat ethanol-preference QTLs (Table 1). There were 4 rat ethanol-preference QTLs that contained 4 or more genes: Alc18 (Ezh2, Gstk1. Gng12, Arhgap25, Tmem176a, Tmem176b); Alc11 (Aadat, Dctd, Sc4mol, Scrg1); Alc15 (Celsr2, Cd53, Lppr5, Ugt8); and Alc5 (Dusp1, Mpg, Slc9a3r2, Tekt4).