to Rett syndrome, a developmental disorder characterized by cognitive deficits similar to autism46. In addition to mir132, Baf53b+/− het mice have alterations in gene expression of other key regulators of the Rac-PAK and RhoA-LIMK pathways, both at the level of the PSD (Grinb2 and Grin2a and Ephrin type-A receptor) and at the level of pathway regulation (Citron and Fhl2). Understanding how exactly BAF53b and the nBAF complex is involved in the regulation of these and other genes will be critical, especially considering that spine abnormalities appear to be a common feature in intellectual disabilities including nonsyndromic intellectual disability, Down, Fragile X, and Rett syndromes47.
