Chunk #11 — Materials and Methods — Discovery study samples, the FTND and quality control

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Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

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For the four samples of non-isolated populations (EAGLE, COPDGene, COGEND and SAGE*), we used the STRUCTURE program24 to compute the ancestral proportions of all study participants using, based on comparison to the HapMap reference populations of Chinese (denoted CHB), European Americans (denoted CEU) and African Americans (denoted ASW) using 10 000 SNPs randomly distributed across the genome. We excluded outlying participants with ⩾25% Asian and/or African American proportions.