Dysfunction in lipid metabolism and glucose homeostasis leads to obesity, which is related to diabetes, hepatic steatosis, hyperlipidemia, and insulin resistance. The liver plays an essential role in the control of glucose and lipid homeostasis. Cytochrome P450 (CYP) enzymes are a family of hemeprotein mainly expressed in liver. Some subfamilies of CYPs contribute to microsomal fatty acid oxidation. CYP4A was found to be contributive to non-alcoholic fatty liver in CYP2E1 knockout mice (ref. 1). CYP2E1 contributes to alcoholic fatty liver (ref. 2–3) and non-alcoholic fatty liver (ref. 4–5). Recently, CYP1B1 was reported to be a new modulator of liver lipid metabolism (ref. 6).
