(re)activity assessed in a number of experimental conditions. Experimental conditions included orthostatic stress (from supine to standing), a startle reflex task92 and the Trier Social Stress Test.93 Physiological measures concerned HR, BP, BRS, pre-ejection period (PEP), respiratory sinus arrhythmia (RSA), eyeblink reflexes (only at startle reflex task) and salivary cortisol (only at the Trier test). Self-reported stress was assessed by the Self-Assessment Manikin,94 the Profiles of Moods Schedule (POMS),95 and the State-Trait Anxiety Inventory (STAI).96PTAdBiological markersCRP, creatinine, ASAT, ALAT, cholesterol (HDL, LDL), glucose, insulin, lipoprotein, HbA1c, platelet serotonin, platelet tryptophan, IgE, IgG antibodies [HSV 1 & 2, EBV, human herpesvirus 6, toxoplasma gondii, influenza (A, B), gliadin, cytomegalovirus, ACTH, alpha-MSH], apoliprotein (A1, B100). Assessed in blood samples.PAFamily characteristicsFamily compositionDevelopmental history interview.cIPSocioeconomic positionParental socioeconomic position. Based on education, profession and income.IQPPHome environmentObserved home environment.c Atmosphere, dirt, luxury, space.OIFamilial psychopathology and distressVignettesc describing depression, anxiety, addiction, antisocial behaviour, psychoses, ADHD and PDD-NOS of biological parents and sibling.IQPPSDepression Anxiety Stress Scales (DASS).97 Depression, anxiety, and stress.QPKessler Psychological distress Scale (K10).98QPChronic conditions of family membersDevelopmental history interview.c Handicaps, chronic diseases, mental health problems.QPLong-term difficulties questionnaire.cQPPPParental happinessRatings of happiness and satisfaction.cQPPFamilial personalityNEO-PI-R.67 Facets vulnerability to stress, hostility, impulsivity, self-consciousness, assertiveness, excitement seeking, gregariousness, competence, self-discipline,