This study found that both PRS and family history were effective in evaluating the risk of AUD and AUD severity, however, there were no significant interactions between them, as shown in a previous study (Johnson et al., 2019). In addition, PRS were still significant after adjusting for family history. All of these indicated that while family history includes at least some genetic component of AUD, PRS provided complementary information, and together they improve the ability to evaluate disease risk as having been demonstrated in previous studies (Abraham et al., 2019, Kachuri et al., 2020, Gronberg et al., 2015, Lu et al., 2018, Moll et al., 2020, Hujoel et al., 2021). As noted previously, early alcohol intervention programs with high risk individuals were effective in reducing the incidence of AUD (Kaner et al., 2007, Kaner et al., 2018, Knox et al., 2019, Welter et al., 2020, Solberg et al., 2008, Whitlock et al., 2004, Cronce and Larimer, 2011, Bersamin et al., 2007), PRS and family history can lead to expedited risk identification, which in turn can guide best practices around these programs, making targeted and personalized prevention strategies possible.
