We found significant enrichment of sentinels in exons and promoters, but not introns and non-promoter intergenic regions (Fig. 6a). There were no significant differences in the location of gene-level as compared to exon-level cis-eQTL signals. We observed the highest enrichment in splice sites and note that this may be a consequence of the ability of our exon-specific array to pick up splicing-level eQTL signals. There was no evidence that the locations were distributed differently between SNPs and indels (data not shown).
