Next we tested whether genes with the strongest association signals were concentrated in known biological or canonical pathways. We performed biological pathway analyses including all genes with a p-value below .01 - this included 304 genes (1.8%) for Harm Avoidance, 351 genes (2.0%) for Novelty Seeking, 276 genes (1.6%) for Reward Dependence, and 279 genes (1.6%) for Persistence. Results indicated that our top genes were not significantly more prevalent in any known biological or canonical pathway.
