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Chunk #4 — Introduction

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Sex differences in genetic architecture of complex phenotypes?
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To test for qualitative sex differences, we focus on dizygotic twin pairs since these siblings are perfectly matched for age, upbringing, and prenatal exposures. For all traits, the resemblance in monozygotic (MZ) twin pairs is also given to establish that familial resemblance is due to genetic factors rather than (or in addition to) shared environment. A first series of analyses is carried out to establish whether DZss and DZos twin pair correlations are the same. If the resemblance in DZos pairs is lower than in DZss pairs, we address the question whether the lower resemblance is due to different genes expressed in men and women or due to the fact that men and women share fewer environmental factors.